Neuropathy

Glucose becomes Sorbitol, first step in diabetic neuropathy Peripheral nerves are metabolically demanding structures. They rely on stable energy production, intact membranes, and consistent antioxidant protection to function properly. In the setting of chronic hyperglycemia, a biochemical shift occurs that places unique stress on these long, vulnerable cells. One of the earliest changes happens in what is known as the polyol pathway . The Polyol Pathway Shift Under normal glu